Spectroscopic and computational studies of nitrile hydratase: insights into geometric and electronic structure and the mechanism of amide synthesis-Reference-Cited by-同舟云学术

Spectroscopic and computational studies of nitrile hydratase: insights into geometric and electronic structure and the mechanism of amide synthesis

Published:2015 Issue:11 Volume:6 Page:6280-6294
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Light Kenneth M.¹²³⁴,Yamanaka Yasuaki⁵⁶⁷⁸,Odaka Masafumi⁵⁶⁷⁸^ORCID,Solomon Edward I.¹²³⁴

Affiliation:

1. Department of Chemistry

2. Stanford University

3. Stanford

4. USA

5. Department of Biotechnology and Life Science

6. Tokyo University of Agriculture and Technology

7. Koganei

8. Japan

Abstract

In addition to its activation of coordinated nitriles, nitrile hydratase utilizes a coordinated sulfenate ligand as a well-oriented nucleophile to form a five-membered intermediate which subsequently undergoes attack by H₂O to ultimately form the amide product.

Funder

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2015/SC/C5SC02012C

Reference39 articles.

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2. Y. Ashina , M.Suto and T.Endo, Nitrile Hydratase, in Encyclopedia of Industrial Biotechnology, ed. M. C. Flickinger, John Wiley & Sons, Hoboken, NJ, 2010, vol. 6, pp. 3671–3676

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4. Biodegradation potential of the genus Rhodococcus

5. Novel non-heme iron center of nitrile hydratase with a claw setting of oxygen atoms

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