Chitosan coated curcumin nanocrystals augment pharmacotherapy via improved pharmacokinetics and interplay of NFκB, Keap1 and Nrf2 expression in Gram negative sepsis

Author:

Shukla Prashant1234,Verma Ajeet K.5234,Dewangan Jayant5234,Rath Srikanta K.5234,Mishra Prabhat R.1234

Affiliation:

1. Pharmaceutics Division

2. Central Drug Research Institute

3. Lucknow 226031

4. India

5. Toxicology Division

Abstract

Chi-CUR-NC provides a viable approach for reducing mortality in cIAI associated Gram negative sepsis.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Reference49 articles.

1. Sepsis: a need for new solutions

2. Chemopreventive and therapeutic effects of curcumin

3. V. P. Menon and A. R.Sudheer in The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer, 2007, pp. 105–125

4. Optimization of novel tocopheryl acetate nanoemulsions for parenteral delivery of curcumin for therapeutic intervention of sepsis

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