Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin
Author:
Affiliation:
1. Centre de Recherche de Gif
2. Institut de Chimie des Substances Naturelles
3. UPR 2301 du CNRS
4. Gif-sur-Yvette Cedex
5. France
6. Departamento de Farmacología
7. Universidad de Alcalá
8. Madrid
9. Spain
Abstract
Hybrids of vinca alkaloids and phomopsin A, linked by a glycine pattern, have been synthesized in one or two steps, by an insertion reaction.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2015/OB/C4OB02114B
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