Structure–activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052-Reference-Cited by-同舟云学术

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Structure–activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052

Published:2023 Issue:10 Volume:14 Page:2030-2034
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Kawagoe Fumihiro¹,Mototani Sayuri¹,Mendoza Aileen²,Takemoto Yasushi²,Uesugi Motonari²³^ORCID,Kittaka Atsushi¹^ORCID

Affiliation:

1. Faculty of Pharmaceutical Sciences, Teikyo University, Itabashi-ku, Tokyo 173-8605, Japan

2. Institute for Chemical Research and Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, Uji, Kyoto 611-0011, Japan

3. School of Pharmacy, Fudan University, Shanghai 201203, China

Abstract

Lack VDR activity and show potent SREBP/SCAP inhibitory activity.

Funder

Japan Agency for Medical Research and Development

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00352C

Reference21 articles.

1. Vitamin D, disease and therapeutic opportunities

2. Vitamin D, calcium homeostasis and aging

3. Vitamin D's role in cell proliferation and differentiation

4. Vitamin D metabolism and signaling in the immune system

5. Vitamin D and the intestine: Review and update

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Improved and scalable synthesis of potent SREBP inhibitor KK-052 via [3+2] cycloaddition;Synthesis;2023-12-28

2. Efficient Stereo-Selective Fluorination on Vitamin D3 Side-Chain Using Electrophilic Fluorination;Biomolecules;2023-12-26

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