Retro-Cope elimination of cyclic alkynes: reactivity trends and rational design of next-generation bioorthogonal reagents-Reference-Cited by-同舟云学术

Retro-Cope elimination of cyclic alkynes: reactivity trends and rational design of next-generation bioorthogonal reagents

Published:2024 Issue: Volume: Page:
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Beutick Steven E.¹²^ORCID,Yu Song¹^ORCID,Orian Laura²^ORCID,Bickelhaupt F. Matthias¹³⁴^ORCID,Hamlin Trevor A.¹^ORCID

Affiliation:

1. Department of Chemistry and Pharmaceutical Sciences, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1108, Amsterdam, 1081 HZ, The Netherlands

2. Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, Padova, 35129, Italy

3. Institute of Molecules and Materials, Radboud University, Heyendaalseweg 135, Nijmegen, 6525 AJ, The Netherlands

4. Department of Chemical Sciences, University of Johannesburg, Auckland Park, Johannesburg 2006, South Africa

Abstract

Diversify your bonds! The reactivity of preactivated cycloalkynes in the retro-Cope elimination reaction was quantum chemically investigated. Based on our finding, we rationally designed a suite of next-generation reagents.

Funder

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Fondazione Cassa di Risparmio di Padova e Rovigo

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/SC/D4SC04211E

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