Role of substituents in the Hofmann–Löffler–Freytag reaction. A quantum-chemical case study on nicotine synthesis-Reference-Cited by-同舟云学术

Role of substituents in the Hofmann–Löffler–Freytag reaction. A quantum-chemical case study on nicotine synthesis

Published:2021 Issue:4 Volume:19 Page:854-865
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Shkunnikova Sofia¹²³⁴,Zipse Hendrik⁵⁶⁷⁸^ORCID,Šakić Davor¹²³⁴^ORCID

Affiliation:

1. University of Zagreb

2. Faculty of Pharmacy and Biochemistry

3. 10000 Zagreb

4. Croatia

5. Department of Chemistry

6. LMU München

7. D-81377 München

8. Germany

Abstract

The Hofmann–Löffler–Freytag (HLF) reaction can be successfully used to synthesize saturated heterocyclic nitrogen-containing nature-derived pharmaceuticals such as nicotine and its derivatives.

Funder

European Cooperation in Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/OB/D0OB02187C

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