Terminal crystalline solid solutions, solubility enhancements and T–X phase diagram of salicylic acid – 4-hydroxybenzoic acid

Author:

Wang Yongjian1ORCID,Ricci Francesco1ORCID,Linehan Brian1,Nordstrom Fredrik L1ORCID

Affiliation:

1. Material & Analytical Sciences, Boehringer-Ingelheim, Ridgefield, 06877, Connecticut, USA

Abstract

T–X phase diagram of salicylic acid – 4-hydroxybenzoic acid with terminal crystalline solid solutions that enhance the solubilities in ACN and 40% MeOH in water by up to 66% over just 0.2% purity change.

Funder

Boehringer Ingelheim

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

Reference28 articles.

1. ASM Handbook , Alloy phase diagrams , ed. H. Baker , ASM International , USA , vol. 3, 2016

2. J. E.Ricci , The Phase Rule and Heterogeneous Equilibrium , D. Van Nostrand Company, Inc ., USA , 1951

3. A tale of two garnets: The role of solid solution in the development toward a modern mineralogy

4. Prevalence of Impurity Retention Mechanisms in Pharmaceutical Crystallizations

5. A. I.Kitaigorodsky , Mixed crystals, Springer Series in Solid-State Sciences , Springer Verlag , vol. 33, 1984

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