Graphene quantum dots obstruct the membrane axis of Alzheimer's amyloid beta

Author:

Tang Huayuan1,Li Yuhuan23,Kakinen Aleksandr4,Andrikopoulos Nicholas3,Sun Yunxiang5ORCID,Kwak Eunbi36,Davis Thomas P.34,Ding Feng1ORCID,Ke Pu Chun346ORCID

Affiliation:

1. Department of Physics and Astronomy, Clemson University, Clemson, SC 29634, USA

2. Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, 200032, China

3. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, VIC 3052, Australia

4. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia

5. School of Physical Science and Technology, Ningbo University, Ningbo 315211, China

6. The GBA National Institute for Nanotechnology Innovation, 136 Kaiyuan Avenue, Guangzhou, 510700, China

Abstract

Graphene quantum dots bind with Aβ, thereby blocking the membrane axis of the peptide and averting downstream pathogenic effects.

Funder

National Institute of General Medical Sciences

National Science Foundation

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry,General Physics and Astronomy

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