Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation-Reference-Cited by-全球学者库

Coordinating bioorthogonal reactions with two tumor-microenvironment-responsive nanovehicles for spatiotemporally controlled prodrug activation

Published:2020 Issue:8 Volume:11 Page:2155-2160
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zuo Liping¹²³⁴,Ding Jingjing¹²³⁴,Li Changkun⁵⁶⁷,Lin Feng⁸⁹¹⁰¹¹¹²,Chen Peng R.⁸⁹¹⁰¹¹¹²^ORCID,Wang Peilin¹²³⁴,Lu Guihong¹²³⁴,Zhang Jinfeng¹²³⁴,Huang Li-Li¹²³⁴^ORCID,Xie Hai-Yan¹²³⁴^ORCID

Affiliation:

1. School of Life Science

2. Beijing Institute of Technology

3. Beijing 100081

4. China

5. Shimadzu (China) Co., Ltd

6. Beijing 100020

7. PR China

8. Peking-Tsinghua Center for Life Sciences

9. Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education

10. College of Chemistry and Molecular Engineering

11. Peking University

12. Beijing 100871

Abstract

Spatiotemporally controlled activation: Dox-TCO loaded low pH-sensitive nanovehicles and Tz-containing MMP-2-sensitive nanocarriers simultaneously dissociated in tumor microenvironment, with Dox locally liberated through IEDDA biorthogonal reaction.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/C9SC05036A

Reference38 articles.

1. The expanding role of prodrugs in contemporary drug design and development

2. Cell-Specific, Activatable, and Theranostic Prodrug for Dual-Targeted Cancer Imaging and Therapy

3. Tetrazine-mediated bioorthogonal prodrug–prodrug activation