A <i>trans</i>-Pt(<scp>ii</scp>) hedgehog pathway inhibitor complex with cytotoxicity towards breast cancer stem cells and triple negative breast cancer cells-Reference-Cited by-同舟云学术

A trans-Pt(ii) hedgehog pathway inhibitor complex with cytotoxicity towards breast cancer stem cells and triple negative breast cancer cells

Published:2022 Issue:47 Volume:51 Page:18127-18135
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Ryan Aisling L.¹²^ORCID,Northcote-Smith Joshua³,McKeon Aoife¹,Roe Andrew⁴,O'Dowd Paul¹²^ORCID,Twamley Brendan⁵,Ní Chonghaile Triona⁴,Suntharalingam Kogularamanan³^ORCID,Griffith Darren M.¹²^ORCID

Affiliation:

1. Department of Chemistry, RCSI, 123 St. Stephens Green, Dublin 2, Ireland

2. SSPC, Synthesis and Solid State Pharmaceutical Centre, Ireland

3. School of Chemistry, University of Leicester, Leicester LE1 7RH, UK

4. Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

5. School of Chemistry, Trinity College Dublin, University of Dublin, Dublin 2, Ireland

Abstract

Hedgehog pathway inhibitor ligand enhances cytotoxicity of trans-Pt(ii) complex towards breast cancer stem cells and triple negative breast cancer cells.

Funder

Irish Research Council

Engineering and Physical Sciences Research Council

Science Foundation Ireland

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/DT/D2DT02865D

Reference37 articles.

1. The rediscovery of platinum-based cancer therapy