Design, synthesis and biological evaluation of new eugenol derivatives containing 1,3,4-oxadiazole as novel inhibitors of thymidylate synthase-Reference-Cited by-同舟云学术

Design, synthesis and biological evaluation of new eugenol derivatives containing 1,3,4-oxadiazole as novel inhibitors of thymidylate synthase

Published:2023 Issue:10 Volume:47 Page:5021-5032
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Alam Mohammad Mahboob¹,Elbehairi Serag Eldin I.²³,Shati Ali A.²,Hussien Rania A.¹,Alfaifi Mohammad Y.²,Malebari Azizah M.⁴,Asad Mohammad⁵⁶,Elhenawy Ahmed A.¹⁷^ORCID,Asiri Abdullah M.⁵⁶^ORCID,Mahzari Ali M.⁸,Alshehri Reem F.⁹,Nazreen Syed¹^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Al-Baha University, Al-Baha, Kingdom of Saudi Arabia

2. Department of Biology, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia

3. Cell Culture Laboratory, Egyptian Organization for Biological Products and Vaccines, VACSERA Holding Company, Giza 2311, Egypt

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia

5. Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

6. Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia

7. Chemistry Department, Faculty of Science, Al-Azhar University, 11884 Nasr City, Cairo, Egypt

8. Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Al Baha University, Al Baha, Saudi Arabia

9. Chemistry Department, Faculty of Science and Art, Al Ula, Taibah University, Al Madinah, Kingdom of Saudi Arabia

Abstract

We report the preparation and cytotoxicity of two new eugenol derivatives that contain 1,3,4-oxadiazole, as novel inhibitors of thymidylate synthase; these derivatives are shown to be promising chemotherapeutic agents.

Funder

King Khalid University

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NJ/D2NJ05711E

Reference47 articles.

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