Self-neutralizing oligonucleotides with enhanced cellular uptake-Reference-Cited by-同舟云学术

Self-neutralizing oligonucleotides with enhanced cellular uptake

Published:2017 Issue:6 Volume:15 Page:1363-1380
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yanachkov Ivan¹²³⁴⁵,Zavizion Boris¹²³⁴,Metelev Valeri¹²³⁴⁶,Stevens Laura J.¹²³⁴,Tabatadze Yekaterina¹²³⁴,Yanachkova Milka¹²³⁴⁵,Wright George⁵²⁷³⁴,Krichevsky Anna M.⁸⁹¹⁰⁴,Tabatadze David R.¹²³⁴^ORCID

Affiliation:

1. ZATA Pharmaceuticals

2. Inc.

3. Worcester

4. USA

5. GLSynthesis

6. Department of Chemistry

7. One Innovation Drive

8. Department of Neurology

9. Brigham and Women's Hospital and Harvard Medical School

10. Boston

Abstract

There is tremendous potential for oligonucleotide (ON) therapeutics, but low cellular penetration due to their polyanionic nature is a major obstacle.

Funder

National Cancer Institute

National Institute of General Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02576E

Reference44 articles.

1. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

2. Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.