Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages-Reference-Cited by-同舟云学术

Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages

Published:2017 Issue:3 Volume:15 Page:701-707
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Páv Ondřej¹²³,Barvík Ivan⁴⁵⁶⁷³,Liboska Radek¹²³,Petrová Magdalena¹²³,Šimák Ondřej¹²³⁸⁹,Rosenbergová Šárka¹²³,Novák Pavel¹²³,Buděšínský Miloš¹²³,Rosenberg Ivan¹²³^ORCID

Affiliation:

1. Institute of Organic Chemistry and Biochemistry of the CAS

2. 16610 Prague

3. Czech Republic

4. Faculty of Mathematics and Physics

5. Institute of Physics

6. Charles University

7. 12116 Prague

8. Department of Chemistry of Natural Compounds

9. University of Chemistry and Technology

Abstract

We utilized the concept of conformational restriction to prepare a set of constrained oligonucleotides derived from 1,4-dioxane and 1,3-dioxolane-locked nucleoside phosphonates and evaluated their hybridization abilities.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02571D

Reference54 articles.

1. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

2. Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

3. An investigation of several deoxynucleoside phosphoramidites useful for synthesizing deoxyoligonucleotides

4. Synthesis of deoxyoligonucleotides on a polymer support

5. S. T. Crooke , Antisense Drug Technology: Principles, Strategies, and Applications, CRC Press, New York, 2008

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