Chemical modification improves the stability of the DNA aptamer GBI-10 and its affinity towards tenascin-C-Reference-Cited by-同舟云学术

Chemical modification improves the stability of the DNA aptamer GBI-10 and its affinity towards tenascin-C

Published:2017 Issue:5 Volume:15 Page:1174-1182
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Li Kunfeng¹²³⁴⁵,Deng Jiali¹²³⁴⁵,Jin Hongwei¹²³⁴⁵,Yang Xiantao¹²³⁴⁵,Fan Xinmeng¹²³⁴⁵,Li Liyu¹²³⁴⁵,Zhao Yi¹²³⁴⁵,Guan Zhu¹²³⁴⁵,Wu Yun¹²³⁴⁵,Zhang Lihe¹²³⁴⁵,Yang Zhenjun¹²³⁴⁵^ORCID

Affiliation:

1. State Key Laboratory of Natural and Biomimetic Drugs

2. School of Pharmaceutical Sciences

3. Peking University

4. Beijing 100191

5. China

Abstract

The aptamer GBI-10 has been modified with d-/l-isoNA or 2′-dI, and its tumor targeting ability in vivo is obviously improved by 4A_L/26T_L/32T_L substitutions.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02577C

Reference49 articles.

1. Tenascin-C induced signaling in cancer

2. Tenascin: An Extracellular Matrix Protein Prominent in Specialized Embryonic Tissues and Tumors

3. Tenascin in normal, reactive, hyperplastic, and neoplastic tissues: Biologic and pathologic implications

4. Tenascin-C Is Expressed in Macrophage-Rich Human Coronary Atherosclerotic Plaque

5. Tenascins: regulation and putative functions during pathological stress

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