Modular synthesis of bicyclic twisted amides and anilines-Reference-Cited by-同舟云学术

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Modular synthesis of bicyclic twisted amides and anilines

Published:2023 Issue:41 Volume:59 Page:6239-6242
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Hindle Alexandra¹,Baj Krzysztof²^ORCID,Iggo Jonathan A.²,Cox Daniel J.³,Pask Christopher M.¹,Nelson Adam¹⁴^ORCID,Marsden Stephen P.¹^ORCID

Affiliation:

1. School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK

2. Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, UK

3. Redbrick Molecular, The Innovation Centre, 217 Portobello, Sheffield, S1 4DP, UK

4. Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, UK

Abstract

A modular approach to the synthesis of twisted bicyclic amides and anilines allows for variation in the degree of overlap between the nitrogen lone pair and the relevant π-system, and hence the structural and physical properties of the products.

Funder

AstraZeneca

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC01470C

Reference39 articles.

1. L.Pauling , The nature of the chemical bond , Cornell University Press , Ithaca , 1940

2. The structure of proteins: Two hydrogen-bonded helical configurations of the polypeptide chain

3. Chemistry of Bridged Lactams and Related Heterocycles

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