Selectivity engineering of the diazotization reaction in a continuous flow reactor

Author:

Shukla C. A.12345,Kulkarni A. A.12345,Ranade V. V.12345

Affiliation:

1. Academy of Scientific and Innovative Research (AcSIR)

2. CSIR-National Chemical Laboratory (NCL) Campus

3. Pune-411008

4. India

5. Chem. Eng. Proc. Dev. Division

Abstract

In situ generated diazonium salts are useful intermediates for the synthesis of fine chemicals and active pharmaceutical ingredients. This paper presents a methodology for selectivity engineering of the diazotization reaction in continuous reactors.

Funder

Council for Scientific and Industrial Research

Publisher

Royal Society of Chemistry (RSC)

Subject

Fluid Flow and Transfer Processes,Process Chemistry and Technology,Chemical Engineering (miscellaneous),Chemistry (miscellaneous),Catalysis

Reference38 articles.

1. L. Kürti and B.Czakó, Strategic Applications of Named Reactions in Organic Synthesis: Background and Detailed Mechanisms, Elsevier Academic Press, 2005

2. Intermolecular Olefin Functionalisation Involving Aryl Radicals Generated from Arenediazonium Salts

3. Recent applications of arene diazonium salts in organic synthesis

4. Continuous-Flow Generation of Anhydrous Diazonium Species:  Monolithic Microfluidic Reactors for the Chemistry of Unstable Intermediates

5. D. F. DeTar , in Organic Reactions, John Wiley & Sons, Inc., 2004, ch. 7, pp. 409–462

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