Design and synthesis of a TICT-based red-emissive fluorescent probe for the rapid and selective detection of HSA in human biofluids and live cell imaging

Abstract

A D⋯π⋯A-based probe, DHMQ, is nonfluorescent in ∼100% PBS due to its TICT behaviour, while it becomes highly fluorescent in the presence of HSA, owing to restriction of its intramolecular free rotation inside the hydrophobic cavity of HSA.