Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways-Reference-Cited by-同舟云学术

Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways

Published:2020 Issue:47 Volume:11 Page:12854-12870
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Bobeica Silvia C.¹²³⁴^ORCID,Zhu Lingyang⁵²³⁴^ORCID,Acedo Jeella Z.¹²³⁴^ORCID,Tang Weixin¹²³⁴^ORCID,van der Donk Wilfred A.¹²³⁴^ORCID

Affiliation:

1. Department of Chemistry and Howard Hughes Medical Institute

2. University of Illinois at Urbana-Champaign

3. Urbana

4. USA

5. School of Chemical Sciences NMR Laboratory

Abstract

To understand factors that determine ring pattern and stereochemistry of thioether cyclization of lanthipeptide natural products, the structures of five prochlorosins (blue) and two enterococcal cytolysins (red) were determined by NMR spectroscopy.

Funder

National Institute of General Medical Sciences

Howard Hughes Medical Institute

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/SC/D0SC01651A

Reference85 articles.

1. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

2. Ribosomally Synthesized and Post-Translationally Modified Peptide Natural Products: New Insights into the Role of Leader and Core Peptides during Biosynthesis

3. Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes

4. Solution structures of the lantibiotics duramycin B and C

5. Structure Determination of an Immunopotentiator Peptide, Cinnamycin, Complexed with Lysophosphatidylethanolamine by 1H-NMR

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