Bottromycins - biosynthesis, synthesis and activity-Reference-Cited by-同舟云学术

Bottromycins - biosynthesis, synthesis and activity

Published:2021 Issue:9 Volume:38 Page:1659-1683
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Franz Laura¹^ORCID,Kazmaier Uli²^ORCID,Truman Andrew W.³^ORCID,Koehnke Jesko¹⁴^ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarland University Campus, 66123 Saarbrücken, Germany

2. Saarland University, Organic Chemistry, Campus Geb. C4.2, 66123 Saarbrücken, Germany

3. Department of Molecular Microbiology, John Innes Centre, Norwich, UK

4. School of Chemistry, University of Glasgow, Glasgow, UK

Abstract

This review summarizes bottromycin research from the 1950s to 2020, including structure elucidation, activity, mechanism of action, total synthesis, biosynthetic gene cluster and biosynthesis, biosynthetic enzymes and heterologous expression.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00097C

Reference132 articles.

1. Bottromycin. I. A New Sulfur-containing Antibiotic

2. Bottromycin derivatives: Efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities

3. Mode of action of bottromycin A2. Release of aminoacyl- or peptidyl-tRNA from ribosomes.