Survival of <i>P. falciparum</i> infected red blood cell aggregates in elongational shear flow-Reference-Cited by-同舟云学术

Survival of P. falciparum infected red blood cell aggregates in elongational shear flow

Published:2024 Issue: Volume: Page:
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Jötten Anna M.¹²,Schepp Anabelle¹,Machon Adam³,Moll Kirsten⁴,Wahlgren Mats⁴,Krüger Timm³^ORCID,Westerhausen Christoph¹⁵⁶^ORCID

Affiliation:

1. Institute of Physics, University of Augsburg, 86159 Augsburg, Germany

2. Faculty of Physics, Ludwig-Maximilians-Universität München, 80539 Munich, Germany

3. School of Engineering, Institute for Multiscale Thermofluids, University of Edinburgh, Edinburgh EH9 3FB, UK

4. Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, 171 77 Stockholm, Sweden

5. Physiology, Institute of Theoretical Medicine, Faculty of Medicine, University of Augsburg, 86159 Augsburg, Germany

6. Center for Advanced Analytics and Predicitve Sciences, University of Augsburg, 86159 Augsburg, Germany

Abstract

Rosette “survival” decreases with longer exposure to elongational flow, increases with rosette size and is 5–15% higher in blood group A. The experimental results are substantiated by a simulation of the underlying protein binding kinetics.

Funder

Center for NanoScience, Ludwig-Maximilians-Universität München

Deutsche Forschungsgemeinschaft

Studienstiftung des Deutschen Volkes

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC00552F

Reference25 articles.

1. Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1

2. Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion

3. Large deforming buoyant embolus passing through a stenotic common carotid artery: A computational simulation

4. Severe falciparum malaria associated with massive pulmonary embolism

5. Cerebral Malaria in Children with Cyanotic Heart Diseases: The Need for a Closer Look