2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations-Reference-Cited by-同舟云学术

2-Hydroxyimino-6-aza-pyrimidine nucleosides: synthesis, DFT calculations, and antiviral evaluations

Published:2020 Issue:45 Volume:44 Page:19650-19662
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Abou-Elkhair Reham A. I.¹²³⁴⁵,Wasfy Abdalla A.¹²³⁴⁵,Mao Song⁶⁷⁸⁹¹⁰,Du Jinxi⁶⁷⁸⁹¹⁰,Eladl Sobhy¹¹¹²³⁴⁵,Metwally Kamel¹¹¹²³⁴⁵,Hassan Abdalla E. A.¹²³⁴⁵,Sheng Jia⁶⁷⁸⁹¹⁰^ORCID

Affiliation:

1. Applied Nucleic Acids Research Center & Chemistry

2. Faculty of Science

3. Zagazig University

4. Zagazig

5. Egypt

6. Department of Chemistry and The RNA Institute

7. University at Albany

8. State University of New York

9. Albany

10. USA

11. Department of Medicinal Chemistry

12. Faculty of Pharmacy

Abstract

Synthesis, DFT calculations, and antiviral evaluation of a series of novel 2-hydroxyimino-6-aza-pyrimidine ribonucleosides is reported. The hydrogen bonding between the C²N–OH moiety and N³–H and/or N³ moieties shapes the pyrimidine nucleoside as purine.

Funder

National Science Foundation

Science and Technology Development Fund

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2020/NJ/D0NJ04154H

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