Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking-Reference-Cited by-同舟云学术

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Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking

Published:2018 Issue:10 Volume:9 Page:1630-1638
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Giancristofaro Antonella¹²³⁴,Barbosa Arménio J. M.⁵⁶⁷⁸⁹^ORCID,Ammazzalorso Alessandra¹²³⁴,Amoia Pasquale¹²³⁴,De Filippis Barbara¹²³⁴,Fantacuzzi Marialuigia¹²³⁴,Giampietro Letizia¹²³⁴,Maccallini Cristina¹²³⁴,Amoroso Rosa¹²³⁴^ORCID

Affiliation:

1. Department of Pharmacy

2. University of Chieti “G. d'Annunzio”

3. 66100 Chieti

4. Italy

5. Chemistry Department

6. Faculdade de Ciências e Tecnologia

7. Universidade Nova de Lisboa

8. 2829-516 Caparica

9. Portugal

Abstract

Three novel FXR agonists are reported, one full agonist, more efficient than the endogenous ligand chenodeoxycholic acid, and two partial agonists.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Fundação para a Ciência e a Tecnologia

Ministério da Ciência, Tecnologia e Ensino Superior

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/MD/C8MD00272J

Reference47 articles.

1. Nuclear Receptors in the Regulation of Lipid Metabolism

2. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home

3. Targeting nuclear receptors for the treatment of fatty liver disease

4. Recent Progress on Bile Acid Receptor Modulators for Treatment of Metabolic Diseases

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