Oxaliplatin and [Pt(R,R-DACH)(panobinostat-2H)] show nanomolar cytotoxicity towards diffuse intrinsic pontine glioma (DIPG)
Author:
Affiliation:
1. Chemistry Research Laboratory
2. University of Oxford
3. Oxford
4. UK
5. Structural Genomics Consortium
Abstract
Oxaliplatin and the platinum(ii) panobinostat complex (2) demonstrate nanomolar cytotoxicity towards diffuse intrinsic pontine glioma cells (DIPG); with 2 exhibiting improved solubility in comparison to panobinostat.
Funder
Wellcome Trust
Cancer Research UK
John Fell Fund, University of Oxford
Publisher
Royal Society of Chemistry (RSC)
Subject
Inorganic Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/DT/C9DT04862F
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