Synthesis of the anionic hydroxypropyl-β-cyclodextrin:poly(decamethylenephosphate) polyrotaxane and evaluation of its cholesterol efflux potential in Niemann

Synthesis of the anionic hydroxypropyl-β-cyclodextrin:poly(decamethylenephosphate) polyrotaxane and evaluation of its cholesterol efflux potential in Niemann–Pick C1 cells

Published:2019 Issue:4 Volume:7 Page:528-537
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Egele Kerstin¹²³⁴,Samaddar Shayak⁵⁶⁷⁸,Schneider Nina⁹¹⁰⁴,Thompson David⁵⁶⁷⁸^ORCID,Wenz Gerhard¹²³⁴^ORCID

Affiliation:

1. Organic Macromolecular Chemistry

2. Saarland University

3. Saarbrücken

4. Germany

5. Dept. of Chemistry

6. Purdue University

7. Lafayette

8. USA

9. BASF SE

10. Ludwigshafen

Abstract

We describe for the first time the homogenous assembly of a water soluble polyrotaxane from HP-β-CD and an anionic posphodiester. The resulting polyrotaxane displays cholesterol normalization activity in NPC cells.

Funder

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2019/TB/C8TB02950D

Reference71 articles.

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3. Use of cyclodextrins in topical formulations: Practical aspects