Unexpected cyclization of ortho-nitrochalcones into 2-alkylideneindolin-3-ones
Author:
Affiliation:
1. Department of Chemistry
2. North Caucasus Federal University
3. Stavropol 355009
4. Russian Federation
Abstract
Highly efficient cascade involving Michael addition and Baeyer–Drewson reaction is triggered by cyanide anion and transforms ortho-nitrochalcones into 2-(3-oxoindolin-2-ylidene)acetonitriles.
Funder
Russian Science Foundation
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/RA/D0RA03520C
Reference52 articles.
1. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases
2. Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease
3. GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
4. Structural Basis for the Synthesis of Indirubins as Potent and Selective Inhibitors of Glycogen Synthase Kinase-3 and Cyclin-Dependent Kinases
5. Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs
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