Unnatural tetradeoxy echinocandins produced by gene cluster design and heterologous expression-Reference-Cited by-同舟云学术

Unnatural tetradeoxy echinocandins produced by gene cluster design and heterologous expression

Published:2023 Issue:17 Volume:21 Page:3552-3556
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Yu Xionghui¹²,Jiang Qian¹²,Chen Xiaona¹²,Shu Hongjun¹²,Xu Yushan¹²,Sheng Huan¹²,Yu Yuchao¹²,Wang Wenjie¹²,Keller Nancy P.³⁴,Xu Jinzhong¹²,Wang Pinmei¹²^ORCID

Affiliation:

1. Ocean College, Zhejiang University, Zhoushan 316021, China

2. Hainan Institute of Zhejiang University, Sanya 572025, China

3. Department of Medical Microbiology and Immunology, University of Wisconsin—Madison, Madison, Wisconsin, USA

4. Department of Bacteriology, University of Wisconsin—Madison, Madison, Wisconsin, USA

Abstract

Heterologous expression of the designed echinocandin biosynthetic gene cluster in the chassis strain results in the production of two novel tetradeoxy echinocandins, one of which has superior stability and antifungal activity to echinocandin B.

Funder

Zhejiang University

Natural Science Foundation of Hainan Province

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/OB/D3OB00075C

Reference21 articles.

1. Echinocandin inhibition of 1,3-β-D-glucan synthase from Candida albicans

2. Echinocandins for the Treatment of Invasive Aspergillosis: from Laboratory to Bedside

3. Echinocandins in antifungal pharmacotherapy

4. CD101, a novel echinocandin with exceptional stability properties and enhanced aqueous solubility

5. Review of the Novel Echinocandin Antifungal Rezafungin: Animal Studies and Clinical Data

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Hadal Streptomyces-Derived Echinocandin Acylase Discovered through the Prioritization of Protein Families;Marine Drugs;2024-05-07