Highly regioselective and diastereodivergent aminomethylative annulation of dienyl alcohols enabled by a hydrogen-bonding assisting effect-Reference-Cited by-同舟云学术

Highly regioselective and diastereodivergent aminomethylative annulation of dienyl alcohols enabled by a hydrogen-bonding assisting effect

Published:2022 Issue:8 Volume:13 Page:2317-2323
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Huang Yao¹,Zou Suchen¹,Yu Bangkui¹,Yan Xuyang¹,Liu Song²^ORCID,Huang Hanmin¹³^ORCID

Affiliation:

1. Department of Chemistry, School of Chemistry and Material Science, Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China, Hefei, 230026, P. R. China

2. Chongqing Key Laboratory of Environmental Materials and Remediation Technologies, Chongqing University of Arts and Sciences, Chongqing, 402160, P. R. China

3. Key Laboratory of Green and Precise Synthetic Chemistry and Applications, Ministry of Education, Huaibei Normal University, Huaibei, Anhui, 235000, P. R. China

Abstract

An efficient hydrogen-bonding assisted directing strategy has been identified, which enables the Pd-catalyzed highly regioselective and diastereodivergent 3,4-difunctionalized aminomethylative annulation of dienyl alcohols with aminals.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D1SC06479G

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