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Engineered protein cages for selective heparin encapsulation

Published:2021 Issue:5 Volume:9 Page:1272-1276
ISSN:2050-750X
Container-title:Journal of Materials Chemistry B
language:en
Short-container-title:J. Mater. Chem. B

Author:

Välimäki Salla¹²³⁴,Liu Qing¹²³⁴,Schoonen Lise⁵⁶⁷⁸^ORCID,Vervoort Daan F. M.⁹¹⁰¹¹¹²⁸,Nonappa ¹³¹⁴²³⁴^ORCID,Linko Veikko¹²³⁴¹³^ORCID,Nolte Roeland J. M.⁵⁶⁷⁸^ORCID,van Hest Jan C. M.⁵⁶⁷⁸⁹^ORCID,Kostiainen Mauri A.¹²³⁴¹³^ORCID

Affiliation:

1. Department of Bioproducts and Biosystems

2. Aalto University

3. Aalto FI-00076

4. Finland

5. Institute for Molecules and Materials

6. Radboud University

7. Heyendaalseweg 135

8. The Netherlands

9. Department of Bio-Organic Chemistry

10. Eindhoven University of Technology

11. Institute of Complex Molecular Systems (ICMS)

12. Eindhoven 5600 MB

13. HYBER Centre

14. Department of Applied Physics

Abstract

Virus capsid proteins modified with a heparin binding peptide can selectively bind and encapsulate heparin inside a protein cage.

Funder

Academy of Finland

Jane ja Aatos Erkon Säätiö

Sigrid Juséliuksen Säätiö

Emil Aaltosen Säätiö

H2020 European Research Council

Ministerie van Onderwijs, Cultuur en Wetenschap

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

Link

http://pubs.rsc.org/en/content/articlepdf/2021/TB/D0TB02541K

Reference47 articles.

1. Re-visiting the structure of heparin

2. Heparin and Low-Molecular-Weight Heparin Mechanisms of Action, Pharmacokinetics, Dosing, Monitoring, Efficacy, and Safety

3. Heparin-Induced Thrombocytopenia: A Review

4. The protamine family of sperm nuclear proteins

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1. HEMA-Lysine-Based Cryogels for Highly Selective Heparin Neutralization;International Journal of Molecular Sciences;2024-06-13

2. Caltrop-like Small-Molecule Antidotes That Neutralize Unfractionated Heparin and Low-Molecular-Weight Heparin In Vivo;Journal of Medicinal Chemistry;2024-02-26

3. Molecular Engineering of E. coli Bacterioferritin: A Versatile Nanodimensional Protein Cage;Molecules;2023-06-09

4. Optically Controlled Construction of Three‐Dimensional Protein Arrays;Angewandte Chemie;2023-05-09

5. Optically Controlled Construction of Three‐Dimensional Protein Arrays;Angewandte Chemie International Edition;2023-05-09

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