Targeting heparin and heparan sulfate protein interactions
Author:
Affiliation:
1. Department of Cellular and Molecular Medicine
2. Glycobiology Research and Training Center
3. University of California
4. San Diego
5. La Jolla
6. Department of Chemistry and Biochemistry
7. USA
Abstract
Heparan sulfate is ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These negatively-charged carbohydrate chains play essential roles in many important cellular functions by interacting with various heparan sulfate binding proteins (HSBP). This review discusses methods for targeting these complex biomolecules, as strategies for treating human disease.
Funder
National Institutes of Health
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB01058C
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