Structural insights into HIV-1 protease flap opening processes and key intermediates
Author:
Affiliation:
1. Drug Discovery and Design Center
2. CAS Key Laboratory of Receptor Research
3. Shanghai Institute of Materia Medica
4. Chinese Academy of Sciences
5. Shanghai
6. UCB Biopharma SPRL
7. Chemin du Foriest
8. Belgium
Abstract
The study provided an integrated view of the transition pathway of the flap opening of HIV-1 protease using MD simulation.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/RA/C7RA09691G
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1. HIV Drug Resistance
2. INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design
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