Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations-Reference-Cited by-同舟云学术

Regioselectivity of hyoscyamine 6β-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations

Published:2020 Issue:14 Volume:49 Page:4454-4469
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Kluza Anna¹²³⁴^ORCID,Wojdyla Zuzanna¹²³⁴^ORCID,Mrugala Beata¹²³⁴^ORCID,Kurpiewska Katarzyna¹²³⁴⁵^ORCID,Porebski Przemyslaw J.¹²³⁴⁶^ORCID,Niedzialkowska Ewa¹²³⁴⁶^ORCID,Minor Wladek⁶⁷⁸⁹^ORCID,Weiss Manfred S.¹⁰¹¹¹²¹³^ORCID,Borowski Tomasz¹²³⁴^ORCID

Affiliation:

1. Jerzy Haber Institute of Catalysis and Surface Chemistry

2. Polish Academy of Sciences

3. PL-30239 Krakow

4. Poland

5. Department of Crystal Chemistry and Crystal Physics

6. Department of Molecular Physiology and Biological Physics

7. University of Virginia

8. Charlottesville

9. USA

10. Macromolecular Crystallography

11. Helmholtz-Zentrum Berlin für Materialien und Energie

12. Berlin

13. Germany

Abstract

Crystal structures and computational results reveal how Hyoscyamine 6β-hydroxylase targets its oxidative power at the C6 position of the tropane ring while sparing the nearby C7 site.

Funder

Narodowe Centrum Nauki

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2020/DT/D0DT00302F

Reference126 articles.

1. The Legacy of Atropos, the Fate Who Cut the Thread of Life

2. Application of Metabolic Engineering to the Production of Scopolamine

3. Production of tropane alkaloids by biotransformation using recombinant Escherichia coli whole cells

4. Efficient biosynthesis of rare natural product scopolamine using E. coli cells expressing a S14P/K97A mutant of hyoscyamine 6β-hydroxylase AaH6H

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