Stromal and tumor immune microenvironment reprogramming through multifunctional cisplatin-based liposomes boosts the efficacy of anti-PD-1 immunotherapy in pancreatic cancer-Reference-Cited by-同舟云学术

Stromal and tumor immune microenvironment reprogramming through multifunctional cisplatin-based liposomes boosts the efficacy of anti-PD-1 immunotherapy in pancreatic cancer

Published:2024 Issue:1 Volume:12 Page:116-133
ISSN:2047-4830
Container-title:Biomaterials Science
language:en
Short-container-title:Biomater. Sci.

Author:

Yu Hang¹,Zhu Wenting¹,Lin Caiyan¹,Jia Menglei¹,Tan Xiaoxiao¹,Yuan Zhongwen¹,Feng Senglin¹,Yan Pengke¹^ORCID

Affiliation:

1. Department of Pharmacy, Biomedicine Research Center, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangzhou, 510150, China

Abstract

Application of ATF decorated cisplatin liposomes and anti PD-1 antibodies to mice with pancreatic cancer showed improved efficacy by enhancing drug penetration and remodeling the immunosuppressive microenvironment.

Funder

Natural Science Foundation of Guangdong Province

National Natural Science Foundation of China

Lin He's New Medicine and Clinical Translation Academician Workstation Research Fund

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/BM/D3BM01118F

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1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries