Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation-Reference-Cited by-同舟云学术

Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation

Published:2019 Issue:2 Volume:10 Page:326-331
ISSN:2040-2503
Container-title:MedChemComm
language:en
Short-container-title:Med. Chem. Commun.

Author:

Beteck Richard M.¹²³⁴⁵^ORCID,Seldon Ronnett⁶²⁷⁸⁵,Jordaan Audrey⁹¹⁰⁷⁵,Warner Digby F.⁹¹⁰⁷⁵¹¹^ORCID,Hoppe Heinrich C.¹¹²³⁴⁵,Laming Dustin¹³³⁴⁵,Legoabe Lesetja J.¹⁴¹⁵¹⁶⁵^ORCID,Khanye Setshaba D.¹²³⁴⁵^ORCID

Affiliation:

1. Faculty of Science

2. Department of Chemistry

3. Rhodes University

4. Grahamstown 6140

5. South Africa

6. Drug Discovery and Development Centre (H3-D)

7. University of Cape Town

8. Rondebosch 7701

9. SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit

10. Department of Pathology

11. Institute of Infectious Diseases and Molecular Medicine

12. Department of Biochemistry and Microbiology

13. Centre for Chemico- and Biomedicinal Research

14. Centre of Excellence for Pharmaceutical Science

15. North-West University

16. Potchefstroom 2520

Abstract

A new series of quinolone-isoniazid hybrid compounds were designed, synthesised and studied for their potential anti-mycobacterial tuberculosis activity in vitro.

Funder

South African Medical Research Council

National Research Foundation

Rhodes University

Publisher

Royal Society of Chemistry (RSC)

Subject

Pharmaceutical Science,Biochemistry,Drug Discovery,Molecular Medicine,Pharmacology,Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2019/MD/C8MD00480C

Reference40 articles.

1. Tuberculosis in Migrant Populations. A Systematic Review of the Qualitative Literature