Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides-Reference-Cited by-同舟云学术

Solid-phase peptide synthesis on disulfide-linker resin followed by reductive release affords pure thiol-functionalized peptides

Published:2022 Issue:29 Volume:20 Page:5699-5703
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Bognar Zsolt¹^ORCID,Mothukuri Ganesh K.¹^ORCID,Nielsen Alexander L.¹^ORCID,Merz Manuel L.¹^ORCID,Pânzar Peter M. F.¹^ORCID,Heinis Christian¹^ORCID

Affiliation:

1. Institute of Chemical Sciences and Engineering, School of Basic Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland

Abstract

Synthesis of peptides on a disulfide linker resin and release by the volatile reducing agent 1,4-butanedithiol offer efficient access to thiol-functionalized peptides needed for peptide labeling, immobilization and cyclization.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

H2020 Marie Skłodowska-Curie Actions

H2020 European Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/OB/D2OB00910B

Reference17 articles.

1. Selective chemical protein modification