Pyrazole-based lamellarin O analogues: synthesis, biological evaluation and structure–activity relationships-Reference-Cited by-同舟云学术

Pyrazole-based lamellarin O analogues: synthesis, biological evaluation and structure–activity relationships

Published:2023 Issue:12 Volume:13 Page:7897-7912
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Dzedulionytė Karolina¹^ORCID,Fuxreiter Nina²,Schreiber-Brynzak Ekaterina²,Žukauskaitė Asta³^ORCID,Šačkus Algirdas¹⁴,Pichler Verena²^ORCID,Arbačiauskienė Eglė¹^ORCID

Affiliation:

1. Department of Organic Chemistry, Faculty of Chemical Technology, Kaunas University of Technology, Radvilėnų pl. 19, LT-50254 Kaunas, Lithuania

2. Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria

3. Department of Chemical Biology, Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic

4. Institute of Synthetic Chemistry, Faculty of Chemical Technology, Kaunas University of Technology, K. Baršausko g. 59, LT-51423 Kaunas, Lithuania

Abstract

Isosteric pyrrole–pyrazole exchange in the natural alkaloid lamellarin O resulted in 18 fully characterized derivatives. Obtained compounds were investigated as potent agents against human colon cancer cell lines HCT116, HT29 and SW480.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA00972F

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