Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite-Reference-Cited by-同舟云学术

Re-examining the role of the gut microbiota in the conversion of the lipid-lowering statin monacolin K (lovastatin) into its active β-hydroxy acid metabolite

Published:2019 Issue:4 Volume:10 Page:1787-1791
ISSN:2042-6496
Container-title:Food & Function
language:en
Short-container-title:Food Funct.

Author:

Beltrán D.¹²³⁴⁵,Frutos-Lisón M. D.¹²³⁴⁵,Espín J. C.¹²³⁴⁵^ORCID,García-Villalba R.¹²³⁴⁵^ORCID

Affiliation:

1. Laboratory of Food & Health

2. Research Group on Quality

3. Safety and Bioactivity of Plant Foods

4. Department of Food Science and Technology

5. CEBAS-CSIC

Abstract

The inter-conversion between MK and MKA depends on the pH whereas MKA was unequivocally catabolised by the gut microbiota.

Funder

Ministerio de Economía y Competitividad

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

Link

http://pubs.rsc.org/en/content/articlepdf/2019/FO/C8FO02594K

Reference24 articles.

1. Development of matrix effect-free MISPE-UHPLC–MS/MS method for determination of lovastatin in Pu-erh tea, oyster mushroom, and red yeast rice

2. The Quantification of Monacolin K in Some Red Yeast Rice from Fujian Province and the Comparison of the Other Product

3. Lovastatin and Simvastatin - Inhibitors of HMG CoA Reductase and Cholesterol Biosynthesis

Cited by 26 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Antimethanogenic activity of Monascus metabolites in the rumen revealed by the concentration of statins, their diversity and the presence of acid forms;Animal Feed Science and Technology;2024-08

2. Quality Control and Safety Assessment of Online-Purchased Food Supplements Containing Red Yeast Rice (RYR);Foods;2024-06-18

3. Dietary supplements: clinical cholesterol-lowering efficacy and potential mechanisms of action;International Journal of Food Sciences and Nutrition;2024-04-24

4. The Lipid-Lowering Efficacy of a Nutraceutical Combination Including Leucoselect Phytosome, Red Yeast Rice, Policosanol and Folic Acid in Dyslipidaemia Patients: Real-World Insights;Pharmaceuticals;2024-03-30

5. The microbiome and cardiovascular disease: Implications in Precision Medicine;Comprehensive Precision Medicine;2024