Development of pipette tip-based on molecularly imprinted polymer micro-solid phase extraction for selective enantioselective determination of (−)-(2S,4R) and (+)-(2R,4S) ketoconazole in human urine samples prior to HPLC-DAD-Reference-Cited by-同舟云学术

Development of pipette tip-based on molecularly imprinted polymer micro-solid phase extraction for selective enantioselective determination of (−)-(2S,4R) and (+)-(2R,4S) ketoconazole in human urine samples prior to HPLC-DAD

Published:2016 Issue:20 Volume:8 Page:4075-4085
ISSN:1759-9660
Container-title:Analytical Methods
language:en
Short-container-title:Anal. Methods

Author:

Santos da Silva Ricky Cássio¹²³⁴⁵,Mano Valdir¹²³⁴⁵,Pereira Arnaldo César¹²³⁴⁵,Costa de Figueiredo Eduardo⁶⁷⁸⁵,Borges Keyller Bastos¹²³⁴⁵

Affiliation:

1. Departamento de Ciências Naturais

2. Universidade Federal de São João del-Rei (UFSJ)

3. Campus Dom Bosco

4. São João del-Rei

5. Brazil

6. Faculdade de Ciências Farmacêuticas

7. Universidade Federal de Alfenas (UNIFAL-MG)

8. Alfenas

Abstract

A simple and selective sample preparation technique employing PT-MIP-μ-SPE coupled to HPLC/DAD was developed for the determination of the cis-enantiomers of ketoconazole in human urine samples.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Engineering,General Chemical Engineering,Analytical Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/AY/C6AY00392C

Reference54 articles.

1. Antimycotic imidazoles. Part 4. Synthesis and antifungal activity of ketoconazole, a new potent orally active broad-spectrum antifungal agent

2. Section Review Anti-infectives: Azole antifungal agents

3. Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan

4. Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes.

5. Ketoconazole-associated hepatic injury

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