Systematic synthetic and biophysical development of mixed sequence DNA binding agents
Author:
Affiliation:
1. Department of Chemistry and Center for Diagnostics and Therapeutics
2. Georgia State University
3. Atlanta
4. USA
5. Janssen Research and Development
6. Department of Pharmaceutical Organic Chemistry
Abstract
Development of heterocyclic diamidines as programmable molecules for sequence-specific DNA recognition.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02390H
Reference41 articles.
1. The Unusual Monomer Recognition of Guanine-Containing Mixed Sequence DNA by a Dithiophene Heterocyclic Diamidine
2. The AT-Hook motif as a versatile minor groove anchor for promoting DNA binding of transcription factor fragments
3. Expanding the specificity of DNA targeting by harnessing cooperative assembly
4. Modulation of NF- B-dependent gene transcription using programmable DNA minor groove binders
5. Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole–Imidazole Polyamide
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