Engineering of spectator glycocalyx structures to evaluate molecular interactions at crowded cellular boundaries

Author:

Honigfort Daniel J.1234ORCID,Zhang Michelle H.1234,Verespy Stephen1234,Godula Kamil1234ORCID

Affiliation:

1. Department of Chemistry and Biochemistry

2. University of California San Diego

3. La Jolla

4. USA

Abstract

Membrane engineering with bystander glycocalyx structures reveals altered protein–receptor association in crowded cell surface environments.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Alfred P. Sloan Foundation

Research Corporation for Science Advancement

Publisher

Royal Society of Chemistry (RSC)

Subject

Physical and Theoretical Chemistry

Reference36 articles.

1. The Structure and Function of the Endothelial Glycocalyx Layer

2. A. Varki and P.Gagneux , Biological functions of glycans , in Essentials of Glycobiology , ed. A. Varki , R. D. Cummings , J. D. Esko , et al. , 3rd edn, Cold Spring Harbor Laboratory Press , Cold Spring Harbor, NY , ch. 7, 2015–2017

3. R. D. Cummings , R. L.Schnaar , J. D.Esko , K.Drickamer and M. E.Taylor , Principles of glycan recognition , in Essentials of Glycobiology , ed. A. Varki , R. D. Cummings , J. D. Esko , et al. , Cold Spring Harbor Laboratory Press , Cold Spring Harbor, NY , 3rd edn, ch. 29, 2015–2017

4. Clusters, bundles, arrays and lattices: novel mechanisms for lectin–saccharide-mediated cellular interactions

5. Nanoscale materials for probing the biological functions of the glycocalyx

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