Amidation of unactivated ester derivatives mediated by trifluoroethanol-Reference-Cited by-同舟云学术

Amidation of unactivated ester derivatives mediated by trifluoroethanol

Published:2017 Issue:16 Volume:15 Page:3507-3518
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

McPherson Christopher G.¹²³⁴,Caldwell Nicola¹²³⁴,Jamieson Craig¹²³⁴^ORCID,Simpson Iain⁵⁶⁷⁴,Watson Allan J. B.¹²³⁴

Affiliation:

1. Department of Pure and Applied Chemistry

2. University of Strathclyde

3. Glasgow

4. UK

5. AstraZeneca

6. Oncology Innovative Medicines

7. Cambridge

Abstract

A catalytic amidation protocol mediated by 2,2,2-trifluoroethanol has been developed, facilitating the condensation of unactivated esters and amines, furnishing both secondary and tertiary amides.

Funder

Engineering and Physical Sciences Research Council

AstraZeneca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C7OB00593H

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