Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of novel indole-2-carboxamides for growth inhibition of Mycobacterium tuberculosis and paediatric brain tumour cells

Published:2021 Issue:26 Volume:11 Page:15497-15511
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Alsayed Shahinda S. R.¹²³⁴⁵^ORCID,Lun Shichun⁶⁷⁸⁹¹⁰,Bailey Anders W.¹¹¹²¹³¹⁴,Suri Amreena¹¹¹²¹³¹⁴,Huang Chiang-Ching¹⁵¹⁶¹⁷¹⁸¹⁴,Mocerino Mauro¹⁹³⁴⁵^ORCID,Payne Alan¹⁹³⁴⁵,Sredni Simone Treiger¹¹¹²¹³¹⁴²⁰^ORCID,Bishai William R.⁶⁷⁸⁹¹⁰,Gunosewoyo Hendra¹²³⁴⁵^ORCID

Affiliation:

1. Curtin Medical School

2. Faculty of Health Sciences

3. Curtin University

4. Perth

5. Australia

6. Center for Tuberculosis Research

7. Department of Medicine

8. Division of Infectious Disease

9. Johns Hopkins School of Medicine

10. Baltimore

11. Division of Pediatric Neurosurgery

12. Ann and Robert H. Lurie Children's Hospital of Chicago

13. Chicago

14. USA

15. Department of Biostatistics

16. Zilber School of Public Health

17. University of Wisconsin

18. Milwaukee

19. School of Molecular and Life Sciences

20. Department of Surgery

Abstract

In this study, we demonstrated that an indoleamide scaffold can be fine-tuned to confer a set of derivatives with selective antitubercular and/or antitumour activities.

Funder

National Heart and Lung Institute

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Australian Research Council

Curtin University of Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/RA/D0RA10728J

Reference62 articles.

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2. Tuberculosis

3. Tuberculosis, Drug Resistance, and the History of Modern Medicine

4. Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

5. The Structure and Interactions of Periplasmic Domains of Crucial MmpL Membrane Proteins from Mycobacterium tuberculosis

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