Enhanced rate of sarcosine <i>N</i>-carboxyanhydride polymerisation from a lysine dendrimer macroinitiator driven by neighbouring H-bonding effects-Reference-Cited by-同舟云学术

Enhanced rate of sarcosine N-carboxyanhydride polymerisation from a lysine dendrimer macroinitiator driven by neighbouring H-bonding effects

Published:2024 Issue:13 Volume:15 Page:1318-1330
ISSN:1759-9954
Container-title:Polymer Chemistry
language:en
Short-container-title:Polym. Chem.

Author:

England Richard M.¹^ORCID,Yu Qing¹,Westley Chloe²,Mallia Carl J.²,Treacher Kevin E.³^ORCID,Norrby Per-Ola⁴^ORCID,Ashford Marianne B.¹^ORCID

Affiliation:

1. Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK

2. Early Chemical Development, Pharmaceutical Sciences, R&D, AstraZeneca, Macclesfield, UK

3. New Modalities and Parenterals Development, Pharmaceutical Technology and Development, Operations, AstraZeneca, Macclesfield, UK

4. Data Science & Modelling, Pharmaceutical Sciences, R&D, AstraZeneca, Gothenburg, Sweden

Abstract

In situ FTIR monitoring revealed that sarcosine N-carboxyanhydride polymerisations were catalysed using a lysine dendrimer macroinitiator owing to hydrogen bonding interactions between the dendrimer core and monomer.

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/PY/D3PY01391J

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