A pillar[5]arene-based [2]rotaxane lights up mitochondria-Reference-Cited by-同舟云学术

A pillar[5]arene-based [2]rotaxane lights up mitochondria

Published:2016 Issue:5 Volume:7 Page:3017-3024
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Yu Guocan¹²³⁴⁵,Wu Dan³⁶⁴⁵⁷,Li Yang³⁶⁴⁵⁷,Zhang Zhihua¹²³⁴⁵,Shao Li¹²³⁴⁵,Zhou Jiong¹²³⁴⁵,Hu Qinglian⁸⁹¹⁰⁷,Tang Guping³⁶⁴⁵⁷,Huang Feihe¹²³⁴⁵

Affiliation:

1. State Key Laboratory of Chemical Engineering

2. Center for Chemistry of High-Performance & Novel Materials

3. Department of Chemistry

4. Zhejiang University

5. Hangzhou 310027

6. Institute of Chemical Biology and Pharmaceutical Chemistry

7. P. R. China

8. College of Biological and Environmental Engineering

9. Zhejiang University of Technology

10. Hangzhou 310014

Abstract

Here we integrate diagnostic and therapeutic agents into a mitochondria-targeting [2]rotaxane, which can be utilized as a drug delivery platform to conjugate anticancer drugs to prepare prodrugs for efficient targeted drug delivery.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/SC/C6SC00036C

Reference67 articles.

1. Measurement of Mitochondrial pH In Situ

2. Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin−TEMPO Conjugates

3. Selective Uncoupling of Individual Mitochondria within a Cell Using a Mitochondria-Targeted Photoactivated Protonophore

4. A mitochondrial pathway for biosynthesis of lipid mediators

5. Ratiometric detection of pH fluctuation in mitochondria with a new fluorescein/cyanine hybrid sensor

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