Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions-Reference-Cited by-同舟云学术

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Published:2017 Issue:1 Volume:15 Page:124-131
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Hayakawa Ichiro¹²³⁴⁵,Saito Keita⁶⁷⁸⁹⁵,Matsumoto Sachiko⁶⁷⁸⁹⁵,Kobayashi Shinichi⁶⁷⁸⁹⁵,Taniguchi Ayaka⁶⁷⁸⁹⁵,Kobayashi Kenichi⁶⁷⁸⁹⁵,Fujii Yusuke⁶⁷⁸⁹⁵,Kaneko Takahiro⁶⁷⁸⁹⁵,Kigoshi Hideo⁶⁷⁸⁹⁵

Affiliation:

1. Division of Applied Chemistry

2. Graduate School of Natural Science and Technology

3. Okayama University

4. Okayama 700-8530

5. Japan

6. Department of Chemistry

7. Graduate School of Pure and Applied Sciences

8. University of Tsukuba

9. Tsukuba 305-8571

Abstract

Second-generation total synthesis of aplyronine A, a potent antitumor marine macrolide, was achieved using Ni/Cr-mediated coupling reactions as key steps.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2017/OB/C6OB02241C

Reference53 articles.

1. Aplyronine A, a potent antitumor substance and the congeners aplyronines B and C isolated from the sea hare Aplysia kurodai

2. Further studies on aplyronine A, an antitumor substance isolated from the sea hare Aplysia kurodai

3. Studies on the stereochemistry of aplyronine A: Determination of the stereochemistry of the C21C34 fragment

4. Absolute Stereochemistry of Aplyronine A, a Potent Antitumor Substance of Marine Origin

5. Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

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