Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme–substrate binding-Reference-Cited by-同舟云学术

Key difference between transition state stabilization and ground state destabilization: increasing atomic charge densities before or during enzyme–substrate binding

Published:2022 Issue:27 Volume:13 Page:8193-8202
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Chen Deliang¹^ORCID,Li Yibao¹,Li Xun¹,Hong Xuechuan²^ORCID,Fan Xiaolin¹,Savidge Tor³⁴

Affiliation:

1. Jiangxi Key Laboratory of Organo-Pharmaceutical Chemistry, Chemistry and Chemical Engineering College, Gannan Normal University, Ganzhou, Jiangxi 341000, China

2. State Key Laboratory of Virology, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery and Hubei Province, Wuhan University School of Pharmaceutical Sciences, Wuhan, 430071, China

3. Department of Pathology & Immunology, Baylor College of Medicine, Houston, TX 77030, USA

4. Texas Children's Microbiome Center, Texas Childrens Hospital, Houston, TX 77030, USA

Abstract

Transition state stabilization and ground state destabilization utilize the same molecular mechanism when lowering the free energy barriers (ΔG‡s) of reactions, but differ in achieving the requirement for ΔG‡ reduction.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangxi Province

National Institute of Allergy and Infectious Diseases

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2022/SC/D2SC01994A

Reference47 articles.

1. Enzyme catalysis: not different, just better