Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects-Reference-Cited by-同舟云学术

Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects

Published:2023 Issue:14 Volume:14 Page:3789-3799
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Zhong Haiping¹,Li Xingwei¹,Yu Na¹,Zhang Xi¹,Mu Jingqing¹,Liu Tao¹,Yuan Bo²³,Yuan Xiaoyong²³⁴,Guo Shutao¹^ORCID

Affiliation:

1. Key Laboratory of Functional Polymer Materials of Ministry of Education, State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin, 300071, China

2. Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Institute, Tianjin Eye Hospital, Tianjin, 300020, China

3. School of Medicine, Nankai University, Tianjin, 300071, China

4. Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, 300052, China

Abstract

Nanoformulated mutual prodrugs able to release two drugs either in order or simultaneously which significantly affected the combination effects consistently in vitro and in vivo, and links the in vitro–in vivo optimization of therapeutic effects.

Funder

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Natural Science Foundation of Tianjin City

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC00550J

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1. Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial