Four Cu(ii) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity-Reference-Cited by-同舟云学术

Four Cu(ii) complexes based on antitumor chelators: synthesis, structure, DNA binding/damage, HSA interaction and enhanced cytotoxicity

Published:2016 Issue:19 Volume:45 Page:8036-8049
ISSN:1477-9226
Container-title:Dalton Transactions
language:en
Short-container-title:Dalton Trans.

Author:

Liu Ya-Hong¹²³⁴⁵,Li Ang¹²³⁴⁵,Shao Jia¹²³⁴⁵,Xie Cheng-Zhi¹²³⁴⁵,Song Xue-Qing¹²³⁴⁵,Bao Wei-Guo¹²³⁴⁵,Xu Jing-Yuan¹²³⁴⁵

Affiliation:

1. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics (Theranostics)

2. School of Pharmacy

3. Tianjin Medical University

4. Tianjin 300070

5. P. R. China

Abstract

Four novel thiosemicarbazone-based Cu(ii) complexes were prepared and all exhibited striking cell viability inhibition and DNA damage, suggesting to be potential promising candidates as antitumor agents.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Inorganic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/DT/C6DT00451B

Reference84 articles.

1. Antimicrobial activity of metals: mechanisms, molecular targets and applications

2. PLATINUM DRUGS TAKE THEIR TOLL

3. Targeted chemical nucleases

4. Chemical nucleases

5. Metalloporphyrins as versatile catalysts for oxidation reactions and oxidative DNA cleavage

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