Synthesis of l-rhamnose derived chiral bicyclic triazoles as novel sodium-glucose transporter (SGLT) inhibitors
Author:
Affiliation:
1. Organic Chemistry Division-II (C P C Division)
2. CSIR-Indian Institute of Chemical Technology
3. Hyderabad
4. India
5. Medicinal Chemistry and Pharmacology Division
6. Laboratory of X-ray Crystallography
Abstract
Fused chiral bicyclic 1,2,3-triazoles synthesized from commercially available natural l-rhamnose exhibited excellent SGLT inhibition activity.
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2014/OB/C4OB01319K
Reference44 articles.
1. Synthesis of 1,2,3-Triazole-Fused Heterocycles via Intramolecular Azide-Alkyne Cycloaddition Reactions
2. Click Chemistry: 1,2,3-Triazoles as Pharmacophores
3. Design and Synthesis of 1,2,3-Triazole-Fused Chiral Medium-Ring Benzo-Heterocycles, Scaffolds Mimicking Benzolactams
4. Copper-Free Intramolecular Alkyne–Azide Cycloadditions Leading to Seven-Membered Heterocycles
5. Regioselective Intramolecular Dipolar Cycloaddition of Azides and Unsymmetrical Alkynes
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