Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly

Author:

Suthar Jugal12ORCID,Alvarez-Fernandez Alberto1ORCID,Osarfo-Mensah Esther13ORCID,Angioletti-Uberti Stefano3,Williams Gareth R.2ORCID,Guldin Stefan1ORCID

Affiliation:

1. Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK

2. UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, UK

3. Department of Materials, Imperial College London, Exhibition Road, London, SW7 2AZ, UK

Abstract

In this work, we are investigating the impact of tailoring the active sites of a biosensor surface to mirror lateral analyte feature sizes, here extracellular vesicles. We relate enhanced sensitivity to reduced steric effects and provide guidelines for future design.

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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