Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly-Reference-Cited by-同舟云学术

Amplified EQCM-D detection of extracellular vesicles using 2D gold nanostructured arrays fabricated by block copolymer self-assembly

Published:2023 Issue:4 Volume:8 Page:460-472
ISSN:2055-6756
Container-title:Nanoscale Horizons
language:en
Short-container-title:Nanoscale Horiz.

Author:

Suthar Jugal¹²^ORCID,Alvarez-Fernandez Alberto¹^ORCID,Osarfo-Mensah Esther¹³^ORCID,Angioletti-Uberti Stefano³,Williams Gareth R.²^ORCID,Guldin Stefan¹^ORCID

Affiliation:

1. Department of Chemical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK

2. UCL School of Pharmacy, University College London, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX, UK

3. Department of Materials, Imperial College London, Exhibition Road, London, SW7 2AZ, UK

Abstract

In this work, we are investigating the impact of tailoring the active sites of a biosensor surface to mirror lateral analyte feature sizes, here extracellular vesicles. We relate enhanced sensitivity to reduced steric effects and provide guidelines for future design.

Funder

Medical Research Council

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

Link

http://pubs.rsc.org/en/content/articlepdf/2023/NH/D2NH00424K

Reference76 articles.

1. Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis

2. ExoCarta: A Web-Based Compendium of Exosomal Cargo