Yeast Saccharomyces cerevisiae adiponectin receptor homolog Izh2 is involved in the regulation of zinc, phospholipid and pH homeostasis

Author:

Mattiazzi Ušaj Mojca123,Prelec Metod123,Brložnik Mojca123,Primo Cecilia456,Curk Tomaž783,Ščančar Janez923,Yenush Lynne456,Petrovič Uroš123

Affiliation:

1. Department of Molecular and Biomedical Sciences

2. Jožef Stefan Institute

3. SI-1000 Ljubljana, Slovenia

4. Instituto de Biología Molecular y Celular de Plantas (IBMCP)

5. Universitat Politècnica de València-Consejo Superior de Investigaciones Científicas

6. Valencia, Spain

7. Faculty of Computer and Information Sciences

8. University of Ljubljana

9. Department of Environmental Sciences

Abstract

Izh2 acts as an integrator of intra- and extracellular signals. It dispatches a single input signal – a change in extracellular Zn concentration – into regulatory networks of several cellular processes, whereby it acts as the second line of cellular adaptation to perturbations to zinc homeostasis.

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Publisher

Oxford University Press (OUP)

Subject

Metals and Alloys,Biochemistry,Biomaterials,Biophysics,Chemistry (miscellaneous)

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